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KMID : 1004320180290020087
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Journal of the Korean Society of Logopedics and Phoniatrics
2018 Volume.29 No. 2 p.87 ~ p.93
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Multicenter Evaluation on the Efficacy of N-Acetyl Cystine in Relieving the Symptoms of Laryngopharyngeal Reflux Disease
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Kim So-Yeon
Kwon Tack-Kyun
Kim Han-Su
Son Young-Ik
Woo Seung-Hoon
Woo Jeong-Soo
Lee Seung-Won
Lim Jae-Yol
Chung Man-Ki
Joo Young-Hoon
Cha Won-Jae
Choi Seung-Ho
Hong Hyun-Jun
Lee Sang-Hyuk
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Abstract
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Background and Objectives: Laryngopharyngeal reflux disease (LPRD) is relatively common disease. N-acetyl cysteine (NAC) has both mucolytic and antioxidant effect, also may be beneficial in inflammatory airway diseases. The purpose of this study was to evaluate the efficacy and safety of inhaled NAC therapy in LPRD.
Materials and Method: We retrospectively reviewed the medical records of 525 LPRD patients at 12 medical centers. Finally 401 patients subjected to inhaled NAC therapy for 2 months were enrolled in the study. We analyzed the change of Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) after use of NAC for 4 weeks and 8 weeks in addition to the patient’s compliance of the treatment.
Results: The RSI score significantly decreased from 19.87±6.34 to 12.78±6.93 after 4 weeks and to 10.65±7.47 after 8 weeks. The RFS score also significantly decreased from 9.29±3.4 to 7.17±3.41 after 4 weeks and to 6.1±3.73 after 8 weeks (p<0.05). During the treatment periods, 42 patients (10.4%) reported to have 80 episodes of discomfort. Throat discomfort (33%) and nausea (28%) were most common complaints, but the duration of discomfort was usually less than 4 weeks.
Conclusion: Inhaled NAC treatment is highly effective for the reduction of both subjective and objective findings in LPRD patients. This study will provide the evidence of new treatment option for patients with LPRD. However, further studies will be needs to assess the real effect of inhaled NAC therapy as a standard treatment regimen of LPRD.
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KEYWORD
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Laryngopharyngeal reflux, N-acetyl cysteine, Inhalation, Treatmen, Symptom
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